Memphis' Easley McCain Studio hosted seminal recording sessions of such artists as Jeff Buckley, Pavement, Sonic Youth and White Stripes, among others.
Firefighters said two blazes at opposite ends of the building ignited Wednesday, apparently because of electrical malfunctions, destroying the studio, which was co-founded by producers Doug Easley and Davis McCain in the early 1990s.
"It's unbelievable. Really, really sad," said Wilco bassist John Stirratt, whose previous band the Hilltops was one of the very first acts to record at Easley McCain.
"If you tried to record in Memphis before Easley, you had to work with, well, 'born-agains.' Easley was the first place to reflect how hip and weird and diverse Memphis really is -- the great, weird underbelly."
Whether the studio would be rebuilt was yet to be determined.