The paper said the former star of "Friends" will direct and star in an episode of the comedy set to air during the November sweeps. He'll play a man who is willing to donate a kidney to his father -- until complications arise.
Perry's father, actor John Perry, will play his father in the episode.
"Scrubs" creator Bill Lawrence told Variety Perry shouldn't worry about first-time directing jitters.
"The guy's timing is ridiculous," said Lawrence, "and our show is all timing-based."
Julianna Margulies, who formerly starred in NBC's medical drama "ER," is scheduled to guest-star in two episodes of "Scrubs" during the November sweeps.