Other guests and presenters will be announced soon, MTV said Wednesday.
"Pirates of the Caribbean: The Curse of the Black Pearl" heads into the night with a leading six nominations, including nods for Best Movie, Best Villain, and Breakthrough Female.
"50 First Dates," "X2: X-Men United," "Finding Nemo" and "The Lord of the Rings: The Return of the King" will battle Johnny Depp's pirate epic for Best Movie honors, MTV noted.
Bill Murray, Tom Cruise, Jim Caviezel, Queen Latifah, Halle Berry, Charlize Theron, Jack Black, Will Ferrell, Will Smith, Martin Lawrence, Ben Stiller, Owen Wilson, Demi Moore, Ludacris, Lindsay Lohan, Jim Carrey and Jennifer Aniston are also among those competing for awards.
The event honoring the year's favorite movies and film performances is scheduled to air on June 10.