About 120 celebrity contributors have given $170,000 for Clooney's campaign as a Democratic candidate in the Fourth Congressional District, the Cincinnati Enquirer reported Sunday.
Hollywood executives also pitched in some funds, such as HBO Chairman Christopher Albrecht, Jeffrey Katzenberg of DreamWorks, Universal Studios President Ronald Meyer and Miramax Films Co-Chairman Robert Weinstein.
Directors Steven Spielberg and Steven Soderbergh have also contributed.
However, his opposition for the congressional seat has been critical of the Hollywood contributions.
"This district wants substance, not celebrity," said Justin Brasell, spokesman for Republican candidate, Geoff Davis.
A spokesman for Nick Clooney's campaign, Bob Doyle, said, "At the end of the day, the people in Northern Kentucky who have known Nick Clooney for years know he is his own man, an independent guy whose views are consistent with the people of his district."