Barrymore co-starred with the "Saturday Night Live" alum in the romantic comedies "The Wedding Singer" and "50 First Dates," due out Friday.
"When I'm having a hard day or need to escape outside of my brain, there are certain types of films that make me feel happy," Barrymore said in production notes for "50 First Dates."
"They are like medicine," she explained. "To me, Adam's films are like a beautiful medicine. I believed with all my heart that we were supposed to make this film. I believe in faith and destiny, but I also feel that you have to gently push things through the channels of the universe."
Barrymore said she fell in love with the film's script, then wrote Sandler a letter telling him she thought they should do the film together.
Celebrity Couples of 2014 [PHOTOS]