The play's spokesman, Jim Byk, said Friday night, that Guy left the production at intermission of Thursday night's preview, for "medical reasons," but he refused further detail, the New York Daily News reported.
"To my deepest regret, I need to leave the production at this time," Guy said in a statement released by Byk.
The 39-year-old actress has appeared in several films and television series but she is best known for her role as Whitley Gilbert Wayne on the series "A Different World," a "Cosby Show" spinoff that began in 1987.
Guy is being replaced by understudy Robin Miles who will now open the show on Nov. 6 at the newly restored Biltmore Theater.
The drama's author, Richard Greenberg, won the Tony Award for best play in June for "Take Me Out."
2014: The Year in Music [PHOTOS]