The "Gangs of New York" director and Barbara De Fina will executive produce the miniseries, which is currently in development and slated for debut in 2005.
"The Twelve" is the story of a rash of mysterious and unexplainable events reported around the world during the 12 days of Christmas. As fear and confusion spread, FBI Special Agent John Ferguson discovers the catastrophes perfectly mirror biblical predictions that suggest the world is coming to an end and Armageddon may occur on the 12th day of Christmas.
Sci-Fi Channel President Bonnie Hammer said, "We're thrilled to be working with Martin Scorsese. He's an icon.
"The dark and thrilling suspense of 'The Twelve' is a perfect match for Scorsese's signature brand of gritty realism."