She tossed her hat in the ring as a potential successor to Hilary Rosen as chairman and chief executive officer of the RIAA, the Web site Hollywoodreporter.com reports.
According to her chief of staff, it "would be a dream job" for the 41-year-old Republican representative from California.
"She hasn't pro-actively gone after the job and RIAA has not yet approached her directly, although friends and colleagues have asked her about it. If RIAA were to do so, it would be very hard for her to turn it down," her spokesman told Billboard magazine.
Bono fulfilled her husband's last term as representative of California's 44th Congressional District after his fatal skiing accident in January 1998. She has since been elected to three more terms.