The Libyan government said a fuel depot near the airport suffered a direct hit after militias armed with heavily artillery surrounded the area.
"This led to the withdrawal of firefighters," Sameer Kamal, spokesperson for the Ministry of Oil, said Sunday.
The spokesman said the smoke and fire could present a major threat to the surrounding area in Tripoli.
At least 200 people have died as a result of fighting between Islamist militias and pro-government forces since July. Foreign governments, including the United States and European powers, have suspended diplomatic operations in Libya because of the recent outbreak of violence.
The interim government in Tripoli said last week it needed outside help in controlling the violence. International forces intervened in Libya's civil war in 2011, sparking the downfall of the regime of Moammar Gahdafi and his eventual death.
The Libyan National Oil Co. said the violence made it difficult to feed the domestic gasoline market, leaving many filling stations without fuel.