The Coast Guard said Philadelphia police notified its offices a train carrying crude oil derailed over a bridge crossing the Schuylkill River.
"There is no report of material leaking from the derailed cars," the Coast Guard said in a statement Monday.
There were no reports in injuries. The Coast Guard said it was notified of the incident early Monday and set up a safety zone around the bridge as a precaution.
The train was operated by rail company CSX Corp. Company spokesman Gary Sease said six of the 101 cars were carrying crude oil and an investigation was under way to determine the cause of the accident, WCAU-TV, Philadelphia, reported.
The train was traveling from Chicago.
A train carrying crude oil exploded after it derailed in North Dakota last month.
The Pipeline and Hazardous Materials Safety Administration, a division of the Transportation Department, issued a safety alert in early January saying the type of crude oil found in North Dakota may be more flammable than other grades.