Sales rose 0.6 percent to $49.9 billion in the month, the fourth increase in five months.
Sales increased in 11 of 21 industries or about 55 percent of the country's manufacturing base.
Sales gains were balanced between durable goods and non-durable goods as each sector rose 0.6 percent, StatsCan said.
Sales of motor vehicle parts rose 2.5 percent to $2 billion, which is shy of the $2.2 billion peak set in June 2012.
Sales of manufactured foods rose 2.6 percent to $7.5 billion in September, the largest gain in nine months.
Gains were pushed by higher sales of grain and oilseed milling, where business picked up as some plants were closed for maintenance in part of August, suppressing sales for that month.