Friday marked the Dow's highest close since Oct.12, 2007. But that quickly eroded Monday after the Census Bureau said factory orders rose less than expected in December, climbing 1.8 percent over November. Economists had predicted a rise of 2.2 percent.
By close of trading, the Dow gave up 129.71 points or 0.93 percent to 13,880.08. The Nasdaq index shed 47.93 points or 1.51 percent to 3,131.17.
The Standard & Poor's 500 lost 17.46 points or 1.15 percent to 1,495.71.
At the New York Stock Exchange, 663 stocks advanced and 2,400 declined on a volume of 3.3 billion shares traded.
The 10-year treasury note was yielding 1.959 percent.
Against the dollar, the euro was $1.3511 from Friday's $1.3651. The dollar was 92.16 yen from 92.78 yen.
In Tokyo, the Nikkei 225 index added 0.62 percent, 69.01 points, to 11,260.35.
In London, the FTSE 100 index dropped 1.58 percent, 100.40 points, to 6,246.84.