The European Union's data agency Eurostat reported unemployment rose October-to-November in the 17-nation currency region, climbing from 11.7 percent to 11.8 percent, a record high.
Despite the report, stocks were mixed in Europe.
By close of trading on Wall Street, the Dow Jones industrial average lost 55.44 points or 0.41 percent to 13,328.85. The Nasdaq composite shed 7.01 points or 0.23 percent to 3,091.81. The Standard and Poor's 500 dropped 4.74 points or 0.32 percent to 1,457.15.
On the New York Stock Exchange, 1,509 stocks advanced and 1,497 declined on a volume of 3.5 billion shares traded.
The 10-year treasury note rose 9/32 to yield 1.871 percent.
Against the dollar, the euro fell to $1.308 from Monday's $1.3117. The dollar was lower at 86.86 yen from 87.79 yen.
In Tokyo, the Nikkei 225 index lost 0.86 percent or 90.95 points to 10,508.06.
In London, the FTSE 100 index fell 0.18 percent, 10.95 points, to 6,053.63.