By close of trading, the Dow Jones industrial average lost 24.49 points or 0.19 percent to 13,114.59. The Nasdaq lost 22.44 points or 0.74 percent to 2,990.16.
The Standard & Poor's 500 shed 6.83 points or 0.48 percent to 1,419.83.
On the New York Stock Exchange, 1,119 stocks advanced and 1,919 declined on a volume of 2.2 billion shares traded.
The 10-year treasury note was up 6/32 to yield 1.756 percent.
Against the yen, the dollar was higher at 85.54 from Monday's 84.81. The euro rose to $1.3228 from $1.3183.
In Tokyo, the Nikkei 225 index added 1.49 percent, 150.24 points, to 10,230.35.
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