In its quarterly "World Economic Outlook" report, the IMF notched its forecast of the global economy's 2012 gross domestic product to show 3.3 percent growth, down 0.2 percentage points from a prediction made in July.
For 2013, the IMF forecast growth of 3.6 percent, down from a previous prediction of 3.9 percent.
By close of trading the Dow Jones industrial average dropped 110.12 points, 0.81 percent, to 13,473.53. The Nasdaq composite index lost 47.33 points, or 1.52 percent, to 3,065.02. The Standard and Poor's 500 index gave up 14.40 points, or 0.99 percent, to 1,441.48.
On the New York Stock Exchange, 703 stocks advanced and 2,358 declined on a volume of 3.1 billion shares traded.
The benchmark 10-year treasury note rose 9/32 to yield 1.72 percent.
The euro fell to $1.2874 from Monday's $1.2969. Against the yen, the dollar fell to 78.24 yen from 78.34 yen.
In Japan, the Nikkei 225 index shed 1.06 percent, 93.71 points, to 8,769.59.
In London, the FTSE 100 index lost 0.54 percent, 41.49 points, to 5,810.25.
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