Markets rose in most of Asia, rising up 2.44 percent in Hong Kong. In Europe, markets opened with brisk gains before falling back on news demand for Spain's benchmark bonds was weak.
The DAX 30 index in Germany, up 0.85 percent early in the day, closed up only 0.17 percent.
Stocks were down in France and flat on the pan-Europe Stoxx 600 index. The FTSE MIB index in Italy fell 2.79 percent.
Markets were up early in New York, but down sharply with sharp slides in late trading.
By close of trading, the Dow Jones industrial average dropped 142.97 points of 1.14 percent to 12,411.23.
The Nasdaq composite shed 48.69 points or 1.7 percent to 2,809.73.
The Standard and Poor's 500 gave up 16.73 points or 1.26 percent to 1,308.93.
On the New York Stock Exchange, 631 stocks advanced and 2,433 declined on a volume of 3.2 billion shares.
The benchmark 10-year treasury note rose 13/32 to yield 1.592 percent.
The euro fell to $1.2482 from Friday's $1.2517. Against the yen, the dollar fell to 79.42 yen from 79.48 yen.
In Tokyo, the Nikkei 225 index added 1.96 percent, 165.65 points, to 8,624.90.
In London, the FTSE 100 index slipped 0.05 percent, 2.71, to 5,432.37.