The bank lost $1.56 billion on residential mortgage-backed securities and $470.1 million in commercial real estate, the Financial Times reported.
Profits in the second quarter a year ago were $2.82 billion, the Times reported.
While other banks are reporting net losses, Deutsche Bank Chief Executive Officer Josef Ackermann said the bank "will not relax our discipline."
In the first quarter, the bank lost $221.1 million but Ackermann said Deutsche was faring well in turbulent times for financial concerns.
"A year has now passed since the beginning of the credit downturn and over this period, Deutsche Bank has earned $4.86 billion in net income," he said.
Other banks are cutting staff but Deutsche ended the second quarter with 2,000 additional employees, the report said.