The asking price is $3.95 million.
Savarino Properties, which listed the home, would not comment when contacted by the Detroit Free Press.
The agency's Web site describes the Mediterranean-style contemporary home built in 1980 as a "breathtaking riverfront estate in the ultimate Ann Arbor location."
Ford and his family moved more than a year ago into a new house near the home they are selling.
His company recently posted a $12.7 billion loss for 2006, its biggest annual loss ever.