The company, which leapfrogged over Monster.com to become the largest U.S. online job site due to the campaign, does not say what marketing ploy will replace the well-dressed if poorly behaved primates.
The commercials have featured a man frustrated with his job because he works with a bunch of monkeys.
The farewell commercials will tell viewers the new campaign will make its debut during the Feb. 4 Super Bowl telecast, The Chicago Tribune reports.
The ape campaign, which vaulted the company into U.S. public consciousness, was launched during the 2005 Super Bowl.
CareerBuilder gets an average of 22 million to 23 million unique visitors a month, the Chicago-based company says, and revenues for the first nine months of 2006 topped $500 million.
In July, CareerBuilder said it passed Monster in revenues -- and attributed the jump in large part to the chimps.