
SEATTLE, March 21 (UPI) -- University of Washington researchers say that about 12 percent of breast cancer patients from high-risk families carry undetected genetic mutations.
These patients tested negative for mutations in the BRCA1 and BRCA2 genes.
Mary-Claire King, one of the authors of the study, said that accurate genetic testing is important in families with a history of breast cancer and ovarian cancer. Preventive measures that can be taken range from early screening for cancer to prophylactic removal of the breasts, an expensive and invasive measure.
"Women at high risk and their clinicians want accurate assessment of genetic risk prior to embarking on ... invasive and expensive risk management options," King and her colleagues wrote. "Our results suggest that genetic testing, as currently carried out in the United States, does not provide all available information to women at risk."
The paper was published in the Journal of the American Medical Association.
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